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4 agosto 2017

Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.

Pietrzik K1, Bailey L, Shane B. Abstract There is a large body of evidence to suggest that improving periconceptional folate status reduces the risk of neonatal neural tube defects. […]
4 agosto 2017

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.

Scaglione F1, Panzavolta G. Author information Abstract Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism. Mammals cannot synthesize folate and depend on supplementation to maintain normal […]
4 agosto 2017

Effects of folic acid supplementation on overall and site-specific cancer incidenceduring the randomised trials: meta-analyses of data on 50,000 individuals.

Vollset SE1 et al. Abstract BACKGROUND: Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. We aimed […]
4 agosto 2017

Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects.

J Matern Fetal Neonatal Med. 2016 Dec;29(23):3894-901. Gong R(1,)(2,)(3), Wang ZP(2), Wang M(4), Gao LJ(2), Zhao ZT(2) To find out the prevention effects of folic acid […]
4 agosto 2017

Effects and safety of periconceptional oral folate supplementation for preventing birth defects.

Cochrane Database Syst Rev. 2015 Dec 14; De-Regil LM1, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P. It has been reported that neural tube defects (NTD) can be prevented with periconceptional folic acidsupplementation. The […]
4 agosto 2017

Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis.

BJOG. 2015 Mar;122(4):478-90 Hodgetts VA(1), Morris RK, Francis A, Gardosi J, Ismail KM To assess the effect of timing of folic acid (FA) supplementation during pregnancy […]
4 agosto 2017

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised,double blind,controlled trial.

04-07-2013 – Lancet 2007; 369: 208–16 Jane Durga, Martin P J van Boxtel, Evert G Schouten, Frans J Kok, Jelle Jolles, Martijn B Katan, Petra Verhoef […]
4 agosto 2017

Circulating unmetabolized folic Acid: relationship to folate status and effect of supplementation.

Obstet Gynecol Int. 2012;2012:485179.Tam C(1), O’Connor D, Koren G.There are increasing concerns that exposure to unmetabolized folic acid, whichresults from folic acid intakes that overwhelm the […]
4 agosto 2017

Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials.

Am J Clin Nutr. 2014 Jan;99(1):96-106. doi: 10.3945/ajcn.113.062752. Epub 2013 Nov 13. Duffy ME, Hoey L, Hughes CF, Strain JJ, Rankin A, Souverein OW, Dullemeijer C, […]